As with fluorescein sodium, these may cause a self limiting mild allergic reaction. The epinastine formulation also contains preservatives called benzalkonium chloride and disodium edetate. As with all medications, there are potential side effects - although uncommon (1 in 10 to 1 in 100 people), there may be a slight burning sensation on application but this temporary and subsides quickly. The anti-allergic drug epinastine hydrochloride (Elestat, Allergan) is a prescription only medicine indicated for the treatment of allergic conjunctivitis. In the unlikely event this does happen the experienced optometrist is immediately available to manage the condition. However it may cause a self limiting mild allergic reaction where the eyes become red, irritated and sore but this is highly unlikely as there are no known reported cases. Fluorescein dye does not sting, lasts only a few minutes and has no effect on vision or driving. The measurements will then be repeated even 5 minutes for an hour.Īfter the final set of measurements, the front surface of your eyes will be assessed using a temporary dye to highlight using a blue light any changes. At each visit, you will experience a different duration (no longer than 10 minutes) and either no treatment, artificial tear supplement (ATS preservative free ocular lubricant), cold compress (CC cooled gel eye mask) or anti-allergic medication (epinastine hydrochloride 500μg/mL). The pollen that you were found to be allergic to will then be introduced into the atmosphere of the room, so that the signs and symptoms of SAC can be induced - this is intentional, but normally resolves within a few hours with no treatment. The redness and temperature of your eyes - the front surface of both eyes will be photographed using digital cameras.Īfter these measurements we will ask you to stand inside a specially designed room where the environment can be controlled by a computer.What symptoms you are feeling and how severe they are - you will be asked to complete a short questionnaire about how your eyes currently feel.At the beginning of each visit, a set of measurements will be taken by an experienced optometrist. There will be a total of 6 study visits, each lasting approximately 1 hour and separated by at least 2 days. Other: Artificial Tear Supplement Device: Cold compress Drug: Anti-allergic Medication At the end of the study the investigators will be able to see whether or not ATS and CC are effective in treating SAC. In addition, the investigators also aim to determine the time course of ocular allergic reactions. Therefore the investigators aim to examine the efficacy of ATS and CC alone, in comparison to anti-allergic medication, and CC in combination with anti-allergic medication. However, there is no evidence in the scientific literature that demonstrates their efficacy compared to no treatment or their combined effect with anti-allergic medication. Treatments that can be used before initiating medical therapy include artificial tear supplements (ATS) and cold compresses (CC). Seasonal allergic conjunctivitis (SAC) is an irritating eye condition that affects many people, caused by hypersensitivity to normally harmless substances such as pollen, and often accompanies seasonal hay fever.
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